Large doses of B vitamins can halve the rate of brain shrinkage in elderly people with memory problems. It may slow their progression toward dementia.
Here, in this latest PloS study, the participants received very high doses of B vitamins. The vitamin pills, which are so potent you can only obtain them with a prescription, contained:
* 800 micrograms (mcg) folic acid -- US RDA is 400 mcg/day
* 500 mcg B12 (cyanocobalamin) – US RDA is only 2.4 mcg/day
* 20 mg B6 (pyridoxine hydrochloride) -- US RDA 1.3-1.5 mg/day
As one of the researchers stated, this is actually "a drug-, not a vitamin intervention."
The study was based on the presumption that by controlling the levels of homocysteine, an amino acid, you might be able to reduce the amount of brain shrinkage, which tends to precipitate Alzheimer's.
High levels of homocysteine are linked to an increased risk of Alzheimer's, as well as heart disease, and stroke.
B vitamins are homocysteine suppressant, and vitamin B12 in particular is known as essential for neurological function.
It seemed to work. After two years, those who had received the vitamin B regimen suffered significantly less brain shrinkage compared to those who had received a placebo.
Well, we know that risk factors for brain atrophy include high blood pressure, diabetes and high cholesterol, and as already mentioned, brain shrinkage typically precipitates the more serious forms of dementia. If you have followed this newsletter you know we are constantly reviewing lifestyle changes to address these risk factors.
Alzheimer's disease is a chronic form of dementia that results in severe memory loss and eventually death. The average lifespan of someone with Alzheimer's is only about eight years, although many can, survive up to 20 years with proper care.
Health conditions associated with Alzheimer's:
* Obesity, especially increased belly fat
* Insulin resistance and diabetes – Diabetics have up to 65 percent higher risk of developing Alzheimer's disease
* Elevated uric acid levels
* Thyroid dysfunction
* Intracellular T3 (immune system cells) deficiency
* Heart disease
Nutritional deficiencies associated with Alzheimers:
* Insufficient omega-3 fats
* Elevated homocysteine levels due to vitamin B6, B12 and folate deficiencies
* Vitamin K deficiency
Environmental toxins associated with Alzheimer's:
* Aluminum toxicity
* Mercury toxicity
One of the factors that I believe are among the most important of all is insulin resistance.
Insulin resistance and/or diabetes is a major factor in elevating your blood pressure, as well as for gaining excess weight; elevating your lipids, blood sugar and uric acid levels; and developing heart disease.
If you are producing too much insulin, you're going to be at risk for all of these health problems—along with brain atrophy and Alzheimer's as well.
Yes, once you begin to see the circular cause and effect relationships between these common health problems, it becomes easier to understand how you can prevent nearly ALL disease, including something as tricky as Alzheimer's.
Special Notes About Vitamin B12
Should you decide to boost your B12 intake with a supplement, please be aware that oral or sublingual B12 tablets do not work very well. Injectable B12 is considered the gold standard, however sublingual sprays are just as effective as the injectable versions and far more convenient and less painful to use.
Interestingly, studies have demonstrated that ginko biloba is effective in the treatment of Alzheimer's disease. One study published in 2006 found that the herb works just as well as Aricept (donepezil) in treating mild or moderate Alzheimer's-related dementia.
# Optimize your vitamin D levels through safe sun exposure, a safe tanning bed and/or vitamin D3 supplements.
# Eat a nutritious diet, rich in folate. Ideally you'll want to design your diet around your nutritional type. Everyone, however, regardless of nutritional type will want to avoid fructose as much as possible.
Strict vegetarian diets have been shown to increase your Alzheimer's risk, whereas diets high in omega-3's lower your risk. However, vegetables, without question, are your best form of folate, and we should all eat plenty of fresh raw veggies every day.
# Eat plenty of high-quality omega-3 fats, such as krill oil. I recommend avoiding most fish, however, because although fish is naturally high in omega-3, most fish stocks are now severely contaminated with mercury.
High intake of the omega-3 fatty acid DHA helps by preventing cell damage caused by Alzheimer's disease, thereby slowing down its progression, and lowering your risk of developing the disorder. Researchers have also said DHA "dramatically reduces the impact of the Alzheimer's gene."
# Keep your fasting insulin levels below 3. There is no question that insulin resistance is one of the most pervasive influences on brain damage, as it contributes massively to inflammation, which will prematurely degenerate your brain.
# Avoid and remove mercury from your body. Dental amalgam fillings are one of the major sources of mercury, however you should be healthy prior to having them removed.
Once you have adjusted to following the diet described in my optimized nutrition plan, you can follow the mercury detox protocol and then find a biological dentist to have your amalgams removed. Please be careful as you could be jumping from the frying pan into the fire like I did if you see a conventional dentist to do the exchange. ONLY see a high quality biologically trained dentist, or your health could be seriously affected.
# Avoid aluminum, such as antiperspirants, non-stick cookware, etc.
# Exercise regularly. According to one study, the odds of developing Alzheimer's were nearly quadrupled in people who were less active during their leisure time, between the ages of 20 and 60. I would strongly recommend reviewing the Peak Fitness Technique for my specific recommendations.
# Avoid flu vaccinations as they contain both mercury and aluminum!
# Eat plenty of blueberries. Wild blueberries, which have high anthocyanin and antioxidant content, are known to guard against Alzheimer's and other neurological diseases.
# Challenge your mind daily. Mental stimulation, especially learning something new, such as learning to play an instrument or a new language, is associated with a decreased risk of Alzheimer's. Researchers suspect that mental challenge helps to build up your brain, making it less susceptible to the lesions associated with Alzheimer's disease.
# Avoid anticholinergic drugs. Drugs that block acetylcholine, a nervous system neurotransmitter, have been shown to increase your risk of dementia. These drugs include certain night-time pain relievers, antihistamines, sleep aids, certain antidepressants, medications to control incontinence, and certain narcotic pain relievers.
A recent study found that those who took drugs classified as 'definite anticholinergics' had a four times higher incidence of cognitive impairment. In those who were not carriers of the specific gene, APOE ε4 allele which I mentioned earlier in this article, the risk was over seven times higher.
http://articles.mercola.com/sites/articles/archive/2010/09/28/high-doses-of-b-vitamins-can-reduce-brain-shrinkage-memory-loss.aspx
Tuesday, September 28, 2010
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